Angiopoietin
Angiopoietin, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. Angptl3 acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), thereby increasing plasma triglyceride, LDL cholesterol and HDL cholesterol in humans. ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
