CUL3 Gene
The CUL3 gene provides instructions for making a protein called cullin-3. This protein plays a role in the cell machinery that degrades unwanted proteins, called the ubiquitin-proteasome system. Ubiquitin serves as a signal to specialized cell structures known as proteasomes, which bind to the tagged proteins and degrade them. The ubiquitin-proteasome system acts as the cell’s quality control system by disposing of damaged, misshapen, and excess proteins. This system also regulates the level of proteins involved in several critical cell activities such as the timing of cell division and growth. Diseases associated with CUL3 include Pseudohypoaldosteronism.
